The recent exposure of "Hainan Boao Yinfeng Kangyang International Hospital involved in the vaccination of fake nine-valent HPV vaccine" has poured a pot of cold water on the vaccination boom of HPV (human papillomavirus) vaccine.

　　Over the past few years, in the upsurge of public opinion, the nine-valent HPV vaccine has gradually become a vaccine "online celebrity". An endless stream of cross-border vaccinators even once "stopped supplying" the nine-valent HPV vaccine in Hong Kong.

　　On April 28th, 2018, under the great expectation, the nine-valent HPV vaccine was officially approved for listing in Chinese mainland at the speed of rocket.

　　Before listing, the huge demand crowd gave birth to chaotic outbound vaccination intermediaries, and illegal smuggling was also common. This industrial chain is still active today.

　　The "fake nine-valent HPV vaccine" incident uncovered the gray side of the HPV vaccine business.

　　According to the notification of Hainan Provincial Health and Health Commission on April 28th, Hainan Boao Yinfeng Kangyang International Hospital (hereinafter referred to as "Yinfeng Hospital") was suspected of illegally vaccinating 38 people with HPV vaccine in January 2018. The "victim" of the incident said that these vaccines may be illegally smuggled or may come from a pharmaceutical factory in Siping, Jilin.

　　In addition, 32 of them are over the recommended vaccination age of nine-valent HPV vaccine (16-26 years old), that is to say, they do not fully understand the protective effect of HPV vaccine. Why do these older women spend nearly 10,000 yuan chasing the nine-valent HPV vaccine of unknown origin?

　　Many experts told The Paper that we should treat the value of the nine-valent HPV vaccine more rationally and need to cool down the "online celebrity" vaccine.

　　Hainan Boao Yinfeng Kangyang International Hospital, sealed by qionghai city Health and Health Commission on April 29th.A Hard-to-Find Nine-valent HPV Vaccine "Myth"

　　Since it was approved on April 28 last year, the strong demand for nine-valent HPV vaccine has triggered an appointment boom in various places, and Beijing, Shenzhen, Hangzhou, Guangzhou and other places have all experienced the phenomenon of "one needle is hard to find".

　　On April 29th, The Paper called the Hubei Provincial Center for Cervical Cancer Prevention and Treatment, and the outpatient department said that it was normal to make an appointment every Monday on the Internet because "there are only a dozen needles at nine prices every week".

　　In many cities, booking a nine-valent HPV vaccine requires a lottery. For example, in Nanning, Guangxi, after winning the lottery, the applicant will be informed of the specific inoculation place and time. If the inoculation is not completed within the specified time, it will be included in ‘ Blacklist ’ You must not participate in the lottery within half a year. "

　　In Shenzhen, from November last year, it was changed from "grab the number to make an appointment" to "shake the number to make an appointment". There were 95,111 valid applicants in the first lottery, and only 1,305 applicants won the lottery, with a winning rate of 1.37%.

　　Behind the "one needle is hard to find" is the publicity upsurge of HPV vaccine that lasted for several years, which even shaped the nine-valent HPV vaccine into a "myth".

　　Since the bivalent HPV vaccine was approved in 2016, titles such as "Ten years waiting, cervical cancer vaccine was finally approved" and "Chinese people waited for ten years, cervical cancer vaccine should not be missed" appeared in the media and occupied the circle of friends.

　　In fact, HPV vaccine has been listed in the United States, Australia and other countries as early as 2006. In 2013, Professor Qiao Youlin from China Academy of Medical Sciences and Institute of Oncology of Peking Union Medical College and his research team published a study in the international authoritative magazine Vaccine, saying that if the cervical cancer vaccine was absent from China for seven years, 380,000 women would miss protection opportunities and become cervical cancer patients in the future if effective intervention measures such as screening were not applied.

　　This research has attracted the attention of the domestic media. Since 2014, there have been reports in China about the long waiting time of cervical cancer vaccine. Until the first HPV vaccine was approved in China in 2016, the listing of tetravalent HPV vaccine in China has also caused widespread concern.

　　Under the ardent expectation of the public, on April 28th last year, the nine-valent HPV vaccine was approved by National Medical Products Administration at "rocket speed". It took only eight days from the acceptance of the marketing application to the conditional approval, setting a new approval record.

　　Who can be vaccinated with nine-valent HPV vaccine? Why is the recommended vaccination age limited to 16-26 years old? How to rationally treat the role of HPV vaccine in preventing cervical cancer? These questions are rarely mentioned.

　　"There is indeed a phenomenon of over-promotion of HPV vaccine. According to the guidance of WHO, it is clear that even if HPV vaccine is vaccinated, cervical cancer cannot be completely avoided." Wang Yuedan, deputy director of the Department of Immunology of Peking University, told The Paper on April 29th.

　　Some experts also pointed out that the frequent reports of vaccine shortage in the media and online have stimulated more women’s desire for vaccination, thus pushing up the market demand and increasing the supply gap.

　　HPV vaccine is only part of the prevention strategy.

　　"Popular Science Questions and Reference Answers about HPV Vaccine" published in National Medical Products Administration official website explained that for most people, being infected with HPV virus is like "getting a cold in the cervix", so there is no need to be too nervous and afraid.

　　"More than 80% of HPV infections will be naturally cleared within 8 months, and only a few persistent high-risk HPV infections can cause cancer for more than 2 years. Among those who continue to be infected, only a few people will develop cervical precancerous lesions, and only a few of the latter will develop into cancer. " Mentioned in the above popular science question and answer.

　　Two experts, Hu Shangying and Qiao Youlin, from the National Cancer Center and Peking Union Medical College Cancer Hospital of China Academy of Medical Sciences, also emphasized that HPV vaccination should be a part of the comprehensive prevention strategy for cervical cancer and other related diseases in a paper "Interpretation of the 2017 WHO HPV vaccine position paper" published in the Chinese journal of preventive medicine. In addition to vaccination, it also includes health education for women to avoid risky behaviors, screening, diagnosis and treatment, training health workers, and improving the accessibility of effective screening and treatment services.

　　For women over the age of 26 who want to get a 9-valent HPV vaccine in China, Liu Fangxun, deputy director of the Department of Special Needs International Medicine of Peking University International Hospital, suggested that they can choose to get a 4-valent HPV vaccine and have a cervical cytology (TCT) examination every year.

　　The best time for HPV vaccination is before sex, that is, before the first exposure to HPV infection. Therefore, teenagers are the best age for HPV vaccination.

　　The recommended vaccination age of bivalent HPV vaccine in China is 9-25 years old women, tetravalent HPV vaccine is suitable for 20-45 years old women, and nonavalent HPV vaccine is suitable for 16-26 years old women.

　　However, the recommended vaccination ages are different in different countries and regions. In the United States, the applicable ages of these three vaccines were all from 9 to 26 when they were first approved. It was not until last October that the indications of the 9-valent HPV vaccine were revised after an average 3.5-year follow-up study targeting 3,200 women aged 27-45. The US FDA approved the application of the 9-valent HPV vaccine to expand the age adaptation range.

　　At present, there is not enough clinical trial data in China to prove that people who are vaccinated with nine-valent HPV vaccine over 26 years old can get the same protective effect as the recommended vaccination age. In Hu Shangying and Qiao Youlin’s aforementioned papers, it is also emphasized that the protective effect of vaccines on older women is lower than that of younger women.

　　On April 28th, 2018, National Medical Products Administration conditionally approved the marketing of nine-valent HPV vaccine for preventing cervical cancer. Unlike bivalent and tetravalent HPV vaccines, the nine-valent HPV vaccine is conditionally approved.

　　Why is it conditionally approved? The nine-valent HPV vaccine is based on the approved data of the previous four-valent HPV vaccine, and it can conditionally accept overseas clinical trial data and bridge with overseas clinical data. Therefore, it is possible to conditionally approve the import registration of products in the shortest time.

　　Among the foreign clinical trials presented in the China instructions of tetravalent HPV vaccine, there is only one phase III trial aimed at the age group of 27-45, and the result is that "the effectiveness of this product in preventing CIN2/3 (cervical precancerous lesion), AIS (adenocarcinoma in situ) or cervical cancer related to HPV16 and 18 in women aged 27-45 has not been confirmed yet".

　　The intermediary chaos caused by huge demand

　　As a group of older women with more purchasing power and spending power, the irrational consumption demand for nine-valent HPV vaccine has also spawned intermediary industries such as "vaccination travel" and overseas vaccination.

　　Tourism websites and medical intermediary companies have launched nine-valent HPV vaccination services in neighboring countries and regions such as South Korea, Singapore, China and Hongkong.

　　In Hong Kong, the upsurge of HPV vaccination due to the "star effect" has also driven the consumption enthusiasm of some mainland women.

　　As early as November 2006, HPV vaccine was approved to be listed in Hong Kong. At the initial stage of listing, public acceptance was not high. According to the data of the Hong Kong Institute of Pharmacists, from November 2006 to 2014, only about 8.85% of women were vaccinated. This situation was reversed in 2015. In 2015, the HPV vaccine subsidy scheme in Hong Kong was fully launched, and eligible people could enjoy the subsidy price as low as HK$ 1,400 per person, with the subsidy rate exceeding 60%.

　　Hongkong also invited many stars to "help out", and G.E.M., Charlene Choi, Ekin Cheng and other stars participated in the production of public service advertisements for many times.

　　Substantial subsidies and celebrity endorsements and publicity have not only greatly increased the number of local vaccinators, but also attracted a large number of mainland women. However, public hospitals in Hong Kong are closed to mainlanders, and this huge consumer group is targeted by many private clinics and intermediaries.

　　In the qualified regular vaccination sites in China, age is a threshold, which blocks this part of the population over 26 years old. Moreover, before the nine-valent HPV vaccine is officially approved in Chinese mainland, it can only be inoculated abroad to get a wider range of titer protection.

　　An endless stream of cross-border vaccinators even once "stopped supplying" the nine-valent HPV vaccine in Hong Kong.

　　The Paper previously reported that from October 12 to December 1, 2017, Merck had directly suspended the supply of nine-valent HPV vaccine in major clinics in Hong Kong, and a large number of mainland consumers who went to Hong Kong for vaccination had disputes with vaccination institutions because of "broken needles".

　　After the unprecedented shortage, the risks of intermediary soliciting customers out of order, no contract documents and difficulties in safeguarding rights are exposed.

　　The age limit is not a problem in many intermediaries. An intermediary who went to Hong Kong to vaccinate the nine-valent HPV vaccine introduced to The Paper: "(Women) can fight if they have menstruation."

　　This chaos is also reflected in the incident of "suspected vaccination of fake nine-valent HPV vaccine" in Yinfeng Hospital.

　　The Paper interviewed 36 female vaccinators in this incident. According to the story, most of the 36 vaccinators were between 20 and 40 years old, and one of them was 49 years old at the time of vaccination. They all recommended each other through acquaintances, paid Wang Lina, who claimed to be the medical staff of Yinfeng Hospital, 900 yuan as the vaccination deposit in advance, and then swiped the card at the involved hospital or transferred 8,100 yuan online, paying a total of 9,000 yuan for the vaccination of this batch of nine-valent HPV vaccines.

　　"9000 yuan should be a random charge." Wang Yuedan said that according to the pricing of domestic nine-valent HPV vaccine, the current price of nine-valent HPV vaccine in the mainland is about 1,300 yuan/needle, and the price of completing three needles is less than 4,000 yuan.

　　In addition to the high premium, there are other risks in vaccination through informal channels in China.

　　According to Hong Kong Ta Kung Pao’s report on April 29th, doctors with unhealthy clinics in Hong Kong, in order to make huge profits, used the genuine nine-valent HPV vaccine produced by Merck Pharmaceutical Factory in the United States to attract mainland customers, and then replaced the genuine nine-valent HPV vaccine with parallel vaccines of unknown origin to vaccinate the guests.

　　"Which institution’s medical staff can fight (over age) means that it is in violation of regulations. If the institution can violate regulations in this place, it may also violate regulations in other links." Liu Fangxun, deputy chief physician of the Special Needs International Medical Department of Peking University International Hospital, told The Paper that vaccine management and cold chain transportation are closely linked in China, which is closely related to the quality and safety of vaccines. Inoculators should choose regular inoculation institutions.

　　Many places have seized HPV vaccine smuggling.

　　In the case of Yinfeng Hospital’s "suspected illegal inoculation of fake vaccines", the source of these nine-valent HPV vaccines became questionable. Victims who had been vaccinated before said, "The vaccines injected in this batch include unknown potions produced by a factory in Siping, Jilin, and smuggled vaccines."

　　At present, Suzhou police have filed a case for investigation. However, the source of the vaccine that is of concern to the outside world has not been disclosed yet.

　　The Paper previously reported that hundreds of people were involved in the vaccine case of Yinfeng Hospital, which was designated by the Ministry of Public Security to supervise the case. Yinfeng Hospital and Qingdao Meibomen House Beauty Information Consulting Co., Ltd. were just one link.

　　According to public reports, cases of illegal entry of "HPV vaccine" have been seized in Shenzhen, Xiamen, Yantai and other places.

　　In May 2017, the airport office of Yantai Inspection and Quarantine Bureau intercepted a number of illegally brought HPV vaccines in the luggage carried by inbound passengers from Taiwan Province.

　　In September 2017, Zhuhai Gongbei Customs officers intercepted two men at the "no declaration channel" at the entry site of Gongbei Port, and found that their suitcases contained a large number of nine-valent vaccines for cervical cancer. This batch of vaccines is placed in three blue heat preservation bags and a transparent sealed bag, some of which are completely boxed and some are in bulk. It is understood that there are more than 220 vaccines in this batch, equivalent to about 130,000 yuan. The passenger concerned failed to provide the vaccine-related approval.

　　In December 2017, the inspection and quarantine staff of Xiamen Airport Inspection and Quarantine Bureau intercepted 201 illegally brought HPV vaccines from the luggage of passengers entering Malaysia.

　　In March 2018, the staff of Shenzhen Huanggang Inspection and Quarantine Bureau seized a group of 45 boxes of nine-valent cervical cancer vaccines brought by passengers at Futian Port, a large number. On-the-spot inspection found that the vaccines were only wrapped in simple plastic bags and packed in backpacks, and no low-temperature cold chain transportation measures were taken, which was easy to degenerate and fail. The passenger said that the vaccine was brought into the country to help people, and it was impossible to explain the source of the vaccine and failed to provide relevant quarantine approval certificates.

　　In November 2018, Xiamen Customs, affiliated to the Airport Customs, intercepted 201 illegally brought HPV (human papillomavirus) vaccines from the luggage of Malaysian inbound passengers, including 150 tetravalent vaccines and 51 nonavalent vaccines. Passengers failed to declare voluntarily and could not provide relevant quarantine certificates.

　　According to the current drug administration law, smuggled vaccines belong to the category of counterfeit drugs.

　　Lawyer Yin Qingli of Beijing Ross Law Firm analyzed that according to Article 39 of China’s Drug Administration Law, if the vaccine comes from abroad, no matter whether it is true or not abroad, as long as there is no import procedure, it can be identified as the scope of counterfeit drugs.

　　In an interview with The Paper, Yin Qingli said that if the "Yinfeng Hospital case" was related to companies and individuals who directly and intentionally violated customs regulations, evaded customs supervision, and transported the vaccines involved in the case in various ways or evaded customs duties, it was not in the form of purchasing by overseas citizens, and there was no special crime of smuggling vaccines and drugs in China, the related companies and individuals might be suspected of committing smuggling in the ordinary sense. If the vaccine in this case is brought to China by an individual through overseas purchasing and used clinically, the so-called overseas purchasing individual should be suspected of selling counterfeit drugs.

　　"Because of the serious harm of counterfeit drugs, on the one hand, it endangers people’s health and life, on the other hand, it also harms the national drug supervision system and market order, so the criminal law makes such a provision. "Yin Qingli explained to The Paper that it is not difficult to see from the above provisions that the crime of producing and selling counterfeit drugs is an act of crime, that is, whether the act of producing and selling counterfeit drugs causes harm to health or not constitutes this crime.

　　Regarding the grey areas where the revised Vaccine Management Law is concerned about whether it can effectively manage vaccine smuggling, a professional who has been engaged in the research of laws and policies related to drug management for a long time told The Paper that in principle, there are special provisions to follow the Vaccine Law, and no provisions are based on the Drug Management Law. "The draft vaccine law has not specifically stipulated the smuggling of vaccines. These incidents will test the integrity of the law." The above personnel said.

2024 Mercedes-Benz G500 changed to six-cylinder G63 eight-cylinder AMG

45 years without major changes in design, it is still a classic today, and its designer is even more relaxed than Porsche’s! That’s right, I’m talking about the Mercedes-Benz G-Class, known as the king of square boxes. Even today in 2024, the Mercedes-Benz G-Class has only come to the third-generation model. Let’s see what new changes this king has!

Pros and cons

advantage

1. Classic design, open the door is a row

2. Off-road capability is unquestionable

3. Luxurious interior atmosphere

disadvantage

G500 changed from V8 to straight 6 engine

The biggest change in this remodel is that the basic version of the G550 (domestic codename G500) has been replaced by a new 3.0T inline six-cylinder turbocharged engine, and a 48V light hybrid system has been added, with a maximum horsepower of 443 horsepower and a peak torque of 560 Nm. Compared with the current G500 on sale, the horsepower has been increased, and the torque has been reduced.

The AMG G63 that countless men dream of is equipped with a new paint color scheme, still powered by a 4.0T V8 twin-turbo engine, and also adds a 48V light hybrid system, providing an additional 15 kW and 200 Nm power assist, and the acceleration time of 0-100km/h is increased from 4.5 seconds to 4.3 seconds.

In addition to the power system, the interior layout has not changed much, but a lot of upgrades have been made. First, the 12.3-inch central control screen has been upgraded to a touch-sensitive display, and the MBUX entertainment system also provides two 11.6-inch rear entertainment screens for rear seat passengers.

In terms of sound system, the new Mercedes-Benz G-Class is equipped with an upgraded Burmester ? 3D surround sound system, optimized speaker layout, new 6 channels, and a speaker with ambient lights is added to the roof lining. With Dolby Atmos ?, it brings visual and auditory upgrades.

There is no need to introduce too much about off-road. Almost no one will take a G-class to go off-road, and the local tyrants who really drive a G-class to go off-road also know more about the off-road capabilities of the G-class.

summarize

As a benchmark for hard-core off-road vehicles, the new Mercedes-Benz G-Class continues to keep pace with the times, retaining strong off-road capabilities, and comprehensively upgrading luxury, intelligence and safety! It is a pity that under the rolling wave of electrification, the classic G500 no longer provides V8 engines, and it is unknown how long the remaining AMG G63 can hold on to V8 beliefs. There will also be pure electric EQGs coming to the market in the future. Hurry up and make money!

Beijing Maybach 4S Store, Mercedes Sales Center

Mercedes-Benz, Maybach AMG Authorized Dealer

Beijing Benz 4S Shop Tel: 010-8178 5588

Key Account Manager of Beijing Mercedes-Benz Maybach 4S Store: 138-1190-6687 Sales nationwide

Address: Beijing Chaoyang District East Third Ring Road Shilihe Bridge 500 meters south 010-8166 1600.

　　Although the Huawei Mate 50 series is nearly 2 years later than expected, according to the rhythm of previous years, Huawei is likely to launch a new generation of P series flagship – Huawei P60 series in Quarter 1 next year. As the release time is approaching, the outside world’s revelations about the machine are also more encrypted. Now there is the latest news. After some appearance and configuration details, digital bloggers have further revealed the appearance of the machine, which is said to be a rendering graph.

　　According to the latest render graph released by a well-known digital blogger, it is basically the same as the previously exposed news. The new Huawei P60 series has changed a lot in appearance design, but it is largely full of the shadow of the previous work. The first is the back of the fuselage. Although the machine continues to use the rear camera module shape of the upper and lower parts, the shape has been changed from the previous "Vientiane Double Ring" to two rounded corner block designs. The upper half contains dual cameras, and the lower half is a lens and flash. On the front of the fuselage, the Huawei P60 adopts the very familiar pill digging scheme, but the position is shifted from the upper left corner to the top center.

　　In other respects, according to the previously exposed news, the new Huawei P60 series is expected to come standard with Qualcomm Snapdragon 8 Gen2 flagship processor, but still only supports 4G network, not 5G. As for other performance parameters, it is not much different from the 5G version of the chip. It is also based on TSMC’s 4nm process. It adopts the new "1 + 2 + 2 + 3" eight-core architecture design. Its Antu running score is expected to break through 1.20 million points, which will bring more powerful performance. In addition, the main camera may use an ultra-large bottom sensor, while the ultra-telephoto may be 64 million pixels. It is also likely to continue to be equipped with the variable aperture launched on the Mate 50 and the Huawei XMAGE self-developed imaging platform. The image performance will be very worth looking forward to.

　　It is reported that the new Huawei P60 series is expected to be available to you in March-April next year. We will wait and see for more details.

1905 movie network feature Recently, the "uncle circle style" has swept across the screen. What impresses people is not only their superb acting skills, but also the unique male charm created by their suits. Different materials, different colors, different styles, and different collar tips, these suit languages not only bring us visual enjoyment, but also convey what information to us? This issue of "Today’s Film Review" invited Jia Xizeng, an associate professor at the Academy of Fine Arts of Tsinghua University, to open the uncles’ wardrobes with us and chat about the sociology in their suits.

What changed was the suit, and it was also an era. The language of the suit was in step with the trend of the times, and the movie Heli showed the clothes between the 1930s and 1940s. This period was the golden age of the suit. During this period, there were many occasions to wear the suit, and the suit even became one of the most common clothes in life.

@Jia Xizeng:In these two films, the matching of suits and the language of costumes are both rigorous and orthodox.

The show is around 2000, when the suit has become fashionable, it not only inherits the tradition, but also adds some contemporary fashion features. By then, the suit in the movie has become a fashion trend and has become a daily trend.

The wardrobe of the movie "Nameless" – showing status and character

The characters in the movie "Nameless" are basically dressed in dark suits, which convey a sense of unity, depth and restraint, which is in line with the plot and style requirements of spy movies. On a poster, standing in front, sitting behind, the three people have different clothing styles. As an underground worker who penetrated the enemy’s interior, Leung Chaowei needed to be calm and low-key, and he wore a six-button barge suit.

@Jia Xizeng:Because he is the first protagonist, the message conveyed by the costume is also the strongest.

Wang Yibo is also wearing a slender head, wearing a wide-shouldered H-shaped (straight), and even a little T-shaped (silhouette) suit, which conforms to the silhouette characteristics of male heroes. The collar of the suit is stiff, like a blade, which matches Wang Yibo’s handsome and bold image. Minister Tang, who plays the role, is more advanced in his attire. By comparing the suits of these three people, we can find that the higher the status, the higher the barge, and the higher the barge. Minister Tang’s attire shows his high position and weight through the design of the collar pin, which instantly distinguishes him from the characters played by Tony Leung and Wang Yibo.

@Jia Xizeng:This is a complete visual language formed by the logical support of color language, clothing language and character language.

Gao Qiqiang’s Wardrobe – The Transformation of Status and Identity

Gao Qiqiang went from being a fish seller to gradually blackening, and his wardrobe was also gradually changing. In the play, Gao Qiqiang’s life is ups and downs. In each period, he has different clothes, the jacket he wears when selling fish, the gray-green suit when the PHS store opens, and the different styles of suits he wears when dealing with different affairs after being instructed by Chen Shuting.

@Jia Xizeng:In fact, clothing is a process of human interaction, so how to reflect etiquette, respect, and a sense of value, through clothing can achieve the finishing touch.

The difference between a barred collar, a flat barred collar and a green fruit collar

In "Hurricane", Gao Qiqiang’s camouflage-collared suit has a particularly high appearance rate. In terms of clothing etiquette, the camouflage-collared suit is of a higher level and shows a greater aura. The camouflage-collared suit is more in line with his role identity. Compared with the camouflage-collared collar, the camouflage-collared collar is more conventional, more low-key, more restrained, and more daily. When Gao Qiqiang attended a leadership meeting in the city, he wore a camouflage-collared suit with a white shirt and no tie, which cleverly avoided high-profile. The green fruit collar is a collared style. It does not have the opening and closing of the neckline. It belongs to a type of dress. It is common on important occasions and is rare in daily life. Last year’s Golden Rooster Awards ceremony was accompanied

People rely on clothes, "Uncle relies on suits", and in future films, we can also figure out the background of the characters from their suits. Li Dapeng wore an orange suit, which is more fashionable and personalized, and is not suitable for daily occasions. In terms of cultural connotation of hue, orange echoes his image of being bohemian on the surface, full of sense of justice in the heart, and enthusiastic about helping others.

In the trailer, Zhu Yilong is wearing casual clothes, but the poster of Zhu Yilong is wearing a formal two-button suit with a white shirt backing, but not a tie. This suit style conflicts with his casual state. It is speculated that it is the director’s deliberate setting, which is intended to suggest that the character played by Zhu Yilong in the movie has different personalities – fickle and hidden.

Dressing is a way of life, but also a way to love life. During the program, Jia Xizeng also shared some clothing suggestions with the audience and friends.

From movies to reality, from the highest ceremonial occasions to daily life, suits have brought us different meanings and values. We also hope that suits can be more everyday, making them a must-have wardrobe that accompanies our daily lives.

Fan Bingbing

　　Movie Network News(Photo/Qian Jia Yiwen/Xie Yawei) On December 14, "October Siege", which has a luxurious lineup of "Nine Emperors and One Queen" in the Chinese film industry, held a grand premiere in Beijing. Producers Chen Kexin, Huang Jianxin, director Chen Desen and starring Liming, Fan Bingbing, Li Yuchun, Liang Jiahui, Nicholas Tse, Hu Jun, Wang Xueqi, Zhou Yun, and Wang Baijie made a collective appearance for the film’s national release on December 18. At the press conference, Fan Bingbing was repeatedly harassed by media reporters, and he was once speechless and embarrassed, while Dawn, who was good at dealing with reporters, took the initiative to fight for Fan Bingbing. When facing the acerbic questions directed at him, he even exploded the thunder of "everyone is from the earth".

Fan Bingbing was embarrassed twice in the face of difficulties, saying that Li Jiaxin was the heroine

　　"The Queen of Topics" Fan Bingbing became the focus of media attention wherever she went. At the press conference, when the media asked her whether she had broken through the "vase" image in this "October Siege" performance, Fan Bingbing said twice in a row that she did not hear the question clearly, whether it was intentional or unintentional. When the question was repeated for the third time, she finally gave the most official answer, "I didn’t think about it that much, I just wanted to shape the character with my heart. In this film, I feel more of the dedication of everyone."

　　"October Siege" brings together the nine best actors in the Chinese film industry, which can be called a man’s play. Compared with the few female actors, the roles of several actresses are rare. Not long ago, after watching "October Siege", Mark Muller, the chairman of the Venice Film Festival, gave Zhou Yun a high evaluation, saying that "Zhou Yun supported the entire" October Siege ". When the reporter asked Fan Bingbing to express his opinion on this comment, Fan Bingbing, who has always been comfortable with the media, first smiled awkwardly, and then replied," I think a movie is not the power of one person, but the work of everyone’s hard work. Success is the result of everyone’s efforts. " Faced with the question of "who is the first heroine", Fan Bingbing immediately blurted out, "I think the real heroine is Li Jiaxin. My mother saw the film yesterday and said that her appearance was amazing." Although the reaction this time was very witty, Fan Bingbing could not hide his embarrassment and smiled unnaturally.

dawn

Hu Jun

Liming stands up for Fan Bingbing, answers questions skillfully and then explodes thunder

　　Fan Bingbing had just been harassed by the media, and then Liming, who was on stage, was also asked the same question, "I never pay attention to the heroine’s problem, I only pay attention to the movie itself." Saying that, he also began to speak up for Fan Bingbing, "I think Fan Bingbing was quite miserable just now. He has been forced by reporters to ask such sharp questions, but it is just practice, and actors always have to face these questions. It is normal to ask such questions, but I am still surprised to keep asking them." The words made the atmosphere of the scene cold for a while.

　　Because Nicholas Tse said in the interview just now that he would take Cecilia Cheung and his son to watch "October Siege", and said that he would not worry about fetal gas, and joked that this film is suitable for all pregnant women to watch. When asked if he would take Leji to watch the movie together, Liming cleverly avoided the reporter’s intention to inquire about gossip, "Sorry, my wife is not pregnant yet, so I won’t take her to see it." Liming was one of the four kings of Hong Kong’s singing scene, but he did not sing the theme song of "October Siege", which would inevitably make some media inquire, and Liming broke out thunder again, causing a burst of laughter at the scene, "Li Yuchun, Tse Tse, they are all very good at singing, they can’t say that the king sings well. Everyone is from earth, and everyone is equal!"

Li Yuchun

Li Yuchun and Xiao Shenyang fight for popularity, Chen Kexin is not afraid of the "three guns" box office rhetoric

　　Li Yuchun was "electrocuted" for the first time in "October Siege", and some remarks said that "Li Yuchun can guarantee at least 50 million box office", while Li Yuchun was very modest, "This film has so many big names, I dare not say such words." In another New Year’s Eve film "Three Guns Shooting Surprise", Xiao Shenyang was called the biggest highlight. Li Yuchun confessed to the media about the popularity of the two. "I can’t answer this. I can only use numbers to explain the problem after the film is released."

　　Zhang Weiping, the producer of "Three Guns Shooting Surprise", made a bold statement in an interview not long ago, "This year’s New Year’s Eve, ‘Three Guns’ will be unstoppable!" And the promotional backboard of "October Siege" on the day of its premiere was also written "Unstoppable". When the media asked if the two films were secretly competing, Chen Kexin replied easily, "These are all propaganda slogans, don’t take them seriously." He said that now our country’s film industry is very prosperous, and it is not difficult for movies to break records at the box office. Nothing is impossible.

Mars Architecture-Super Hybrid Platform clarifies the direction of Chery’s hybrid and fuel production in the next five years. In terms of forward-looking wisdom, the Mars architecture-super hybrid platform is equipped with the flagship chip of Qualcomm Snapdragon 8155 in the automotive performance ceiling, and the CPU computing power reaches 105 K; Equipped with self-evolving EEA4.0 electronic and electrical architecture, it supports 5G and Gigabit Ethernet. At the same time, the new platform products are also equipped with Chery Pilot L2.9 intelligent driving assistance system, including 21 basic ADAS functions and 11 advanced intelligent driving functions.

On March 13th, 2024, A-share online game concept stocks surged at the beginning of the session, and the game ETF(159869) has now risen by over 2%. Recently, the game sector continued to rebound and attack, and the game ETF(159869) continued to pay a premium in intraday trading. Yesterday, the net inflow of funds exceeded 100 million yuan, and the signal of fund layout was obvious.

In the news, the Global Game Developers Conference (GDC) will be held in San Francisco from March 18th to March 22nd. The conference will cover many topics such as AI, VR, AR, audio, vision, programming, etc. The participating manufacturers include Microsoft, Google, NVIDIA, Meta, Adobe, EPIC, Unity, Roblox, Tencent and Netease. Citic Jiantou pointed out that looking back at the GDC conference in 2023, AI became the biggest keyword, and industry head companies such as Microsoft, Ubisoft and Roblox shared how AI innovated game production/operation, including reducing costs and increasing efficiency, and creating new gameplay, which also drove the A-share game sector to rise sharply. Focus on the catalysis of this year’s GDC conference on the game sector. As can be seen from the theme of the conference, AI has penetrated into more production links and more game categories.

　　Looking for dark matter, machines are better than human eyes. A recent paper published in Computational Astrophysics and Cosmology shows that the deep learning AI framework jointly developed by Lawrence Berkeley National Laboratory (hereinafter referred to as Berkeley Laboratory) can explore the signs of dark matter in the universe.

　　In recent years, artificial intelligence has been increasingly applied to astronomical research. Deep learning requires massive amounts of data, and astronomy is the field where AI shows its talents. Machines can find a needle for human beings from the vast ocean and capture new stars, new extraterrestrial planets and even dark matter.

　　Recognizing the "gravitational lens", AI has made contributions.

　　Finding "gravitational lens" is the basic method to study the distribution of dark matter. An object with a huge mass will distort the passing light like a lens, and if we find out this distortion, we can capture the non-luminous mass.

　　The paper shows that CosmoGAN, a deep learning AI framework established by Berkeley Lab, can analyze the relationship between gravitational lens and dark matter. It can create high fidelity and weak gravitational lens convergence diagram.

　　Once upon a time, it was troublesome to find the simulation and data processing needed for the "gravitational lens". Twenty scientists spent months looking at only a small space image. Physical simulation takes billions of computing hours and takes up megabytes of disk space.

　　The progress of neural network provides opportunities. The team led by Berkeley Lab introduced a "generative confrontation network (GANs)". Researcher Mustafa said: "There are other deep learning methods that can get convergence graphs from many images, but compared with competitive methods, GANs generates very high-resolution images while still having the high efficiency of neural networks."

　　Now, astronomers can use CosmoGAN to analyze a much larger sky area, and the speed is faster.

　　CosmoGAN is not the only astronomical deep learning neural network that has made progress. For example, the University of Toronto used deep learning technology to analyze satellite images of lunar craters, and the neural network of P8 supercomputer discovered 6,000 new craters in just a few hours, twice the number of craters discovered by humans in the past decades. The University of Illinois at Urbana-Champaign uses deep learning to detect and analyze gravitational waves of black hole collisions. AI blooms everywhere in astronomy.

　　There is too much data to play without a machine.

　　In the past few years, most directions in the field of astronomy have tried to use artificial intelligence. Considering the amount of data that astronomy has to deal with, this is a natural idea. Let the machine practice to analyze clues, otherwise, astronomy in the future will not work.

　　The 2019 GPU Technology Conference held not long ago attracted artificial intelligence scholars all over the world. Brent Robertson, an astronomer from the University of California, Santa Cruz, was invited to give a speech at the conference. He pointed out: "Astronomy is at the cusp of a new data revolution". Robertson believes that the new generation of astronomical instruments must cooperate with the new generation of software driven by deep learning.

　　For example, the large-caliber all-day patrol telescope (LSST) is expected to run in three years. It toured 37 billion galaxies in the southern half of the universe, generating a ten-year uninterrupted video. LSST is equipped with a 3.2 billion pixel camera, which generates 25TB of data every night, which is equivalent to all the data contributed by the advanced astronomical telescope in a lifetime.

　　Another example is the Square Kilometer Array Radio Telescope (SKA). It is spread all over the world, some antennas are deployed in eight countries in southern Africa, and more than one million antennas are located in Australia and New Zealand. Its raw data reaches 5000 PB every day, and there are about 50 PB after processing.

　　"Dark Energy Survey" compiles star maps of hundreds of millions of galaxies; "Gaia" satellite surveying and mapping stars with galactic coefficient of one billion; The "Zwicky" project can scan 3,750 square degrees of sky every hour. In China, the daily data volume of FAST will reach 150TB；; Guo Shoujing telescope has observed 9.01 million spectra, which is the largest celestial spectrum library in the world … …

　　Capture patterns that humans can’t see.

　　There are more and more data, and scientists try to aggregate them. However, at the GPU conference, Robertson said that in the future, several large astronomical telescopes will produce a large amount of data together, which is too complicated for human beings to directly use after aggregation. Scientists at the University of California, Santa Cruz, tried to solve this problem. Morpheus deep learning framework created by a doctoral student in computer science department can classify celestial bodies pixel by pixel based on the original data of telescope.

　　Scientists at the University of California, Santa Cruz, also use AI to better study the formation of galaxies. In a study published in early 2019, scientists trained computers with computer-simulated galaxies to learn three key stages of galaxy evolution. Later, computer analysis of galaxy images from the Hubble Space Telescope performed surprisingly well.

　　Artificial intelligence is applied to face recognition. After training with massive data, you can recognize this person’s makeup and old age according to a photo. And many images in the universe can be classified in the same way.

　　"Deep learning can look for patterns, and machines can see very complicated patterns that humans can’t see." David Ku, a scientist involved in the research, said, "We hope to further test this method. In the proof-of-concept study, the machine seems to have successfully found the different stages of galaxy evolution determined in the simulation in the data. "

　　Help astronomers find another solar system

　　A report at the end of 2018 showed that Google artificial intelligence made efforts to find new planets from Kepler’s exoplanet observation database. Planets are hard to find. Kepler satellite in space observes 145,000 sun-like stars, and finds planets from the faint changes of star brightness. The data recorded for four years includes about 35,000 suspected planetary records. Astronomers use machines combined with human eyes to identify, but the darkest and weakest signals are often ignored.

　　With the help of Google AI, we discovered two new planets, Kepler 90i and Kepler 80g. Kepler 90 was also recognized as the first exogalaxy with at least eight planets.

　　Neural network and machine learning processed 14 billion data points, and then successfully screened out candidates.

　　NASA and Google say that new technologies will find more exoplanets in the future. NASA also said that there is no need to worry about astronomers losing their jobs. Jesse Dotson, a scientist at NASA, explained that astronomers need to classify data before they are provided to neural networks, so that artificial intelligence can learn and analyze new information from them.

　　Dotson said: "AI will definitely work with astronomers in the future and become an indispensable tool."

　　Of course, machine learning also brings the risk of "black box": we get the answer, but we don’t know why the machine makes such a judgment, and maybe the answer is wrong. Machines make mistakes. Astronomers will continue to train and adapt to it.

　　Extended reading

　　Expert comments

　　Deep learning does not have "physical intuition"

　　Indeed, artificial intelligence has now penetrated into all branches of astronomy and astrophysics. At present, Lawrence Berkeley National Laboratory in the United States can quickly judge the basic cosmological constants such as dark matter and dark energy according to the three-dimensional density distribution of the universe by using deep learning. They found that after applying artificial intelligence, the statistical error is much smaller than that of the traditional statistical methods. In addition, we also use deep learning to search for hydrogen and carbon elements in the early universe in the spectrum with extremely low signal-to-noise ratio, and find that it is better than the traditional method.

　　At the same time, astronomers are also applying deep learning to help us judge the three-dimensional position and distance of celestial bodies, and then outline the large-scale structure of three-dimensional space. It is found that deep learning may be stronger than the traditional methods we used before in mining data and information. Artificial intelligence has also been applied to the field of detecting exoplanets by Google, and several exoplanets … … It can be said that artificial intelligence is now widely used in the frontier field of astrophysics.

　　But from the physicist’s point of view, artificial intelligence based on deep learning may also have its limitations. This limitation is that it can only play a role in a specific field that has been very clearly defined based on data. Only under the guidance of physicists, we can make the error bar of statistics smaller and estimate a certain quantity more accurately, but at present we can’t guide us to discover the new physical laws behind the data. Nor does it have a "physical intuition" based on beauty, symmetry and simplicity that is unique to humans.

　　To give a simple example, for example, Kepler’s observation data based on Tycho can find Kepler’s third law, and even the best machine learning and artificial intelligence algorithms at present may be difficult to repeat this discovery based on the same data.

　　Therefore, I think that the essence of the application of deep learning in astronomy is still limited to doing better statistics and fitting.

　　(Professor Cai Wei, Department of Astronomy, Tsinghua University)

At 2pm on 23rd, the China men’s soccer team visited Auckland to challenge New Zealand, which ranked 105th in the world. 0-0, the two teams drew a blank. The performance of the national football team is still qualified, with Lei Wu and Wei Shihao on the offensive end and Wei Zhen on the defensive end playing well. Especially in the 62 nd and 64 th minutes, two minutes of attack and defense won applause from the national football fans at the scene.

Two hours before the national football competition, the younger brother U24 lost the national football team 0-2 to New Zealand U22, but he couldn’t beat the other team. As a big brother, the national football team can’t afford to lose-if it loses, it will take four hours and two defeats, and the China men’s football team will even lose its head.

Lei Wu’s anti-aircraft guns.

Wei Shihao’s free kick is higher than that.

In the opening stage, the national football team is still the same, it is difficult to pass more than three feet in a row, and the scene is very passive. Except for Wei Shihao, the frontcourt attack lacks bright spots. After Yi Bian fought again, the national football team seized a mistake made by New Zealand and reversed the trend:

In the 63rd minute, New Zealand passed the ball and played with fire in the backcourt, and Lei Wu staged speed master to steal the ball before New Zealand captain Smith. Smith put Lei Wu down behind his back. Lei Wu, sitting on the ground, made a gesture of "penalty card", and the referee directly sent Smith off with a red card!

Lei Wu made Smith’s red card with his speed and agility, creating a situation of 11-10 for the national football team. China fans at the Intelligent Mountain Stadium burst into applause and cheers. Lei Wu’s performance was recognized by the fans.

Just 2 minutes later, New Zealand also made a quick counterattack and formed an excellent opportunity for 1V1! Fortunately, Wei Zhenguo, the national football defender, broke the shovel and made a wonderful steal from behind.

For Wei Zhen’s shovel, the New Zealand broadcaster commentator shouted: "wonderful, what a beautiful shovel break! What a tackle）！” Wei Zhen also high-fived his teammates to celebrate.

Wu Xi, captain of the national football team

For the national football team, this is a crucial defense: if Wei Zhen fouls, it is likely to be a red dot package, and the confidence and number advantage that the national football team has just established will be ruined in an instant. Fortunately, Wei Zhen’s tackle was clean and very uplifting!

Although China’s men’s soccer team is always criticized and ridiculed by fans, judging from these two minutes of attack and defense, the performance of the national football team is obviously better than that of New Zealand. Lei Wu swoops down and steals the ball from New Zealand captain Smith, who pulls down Lei Wu behind him and is sent off with a red card. In a blink of an eye, New Zealand’s fast break and Wei Zhen’s back tackle were textbook defense.

11 to 10 has become the key for the national football team to reverse the situation. Unfortunately, the fierce attack of the national football team failed to get a goal. China fans are not demanding, and 0-0 is acceptable. The national football fans at the scene also applauded the national football team …

　　Entrusted the owner of the lottery shop to buy lottery tickets on his behalf, but he won 14 million prizes. But when I wanted to get the lottery ticket, I found that the boss couldn’t contact me, and even the lottery shop was closed. Upon further inquiry, the winning lottery ticket went to the boss’s friend.

　　The boss took the lottery and ran away? Or do you want to swallow the grand prize? Who finally won the 14 million prize?

　　Yesterday, a reporter from qianjiang evening news came to this small lottery shop in Shengzhou. On November 10th, five days after closing, the lottery shop reopened. After this big prize storm, Xiao Xu, the post-90 s boss, was a little tired. He said, "If the sports lottery shop stops, I may never know for a lifetime, but I am willing to stand up and deal with this crisis."

　　Won more than 14 million yuan.

　　I can’t get the lottery ticket.

　　Things should start from November 5.

　　Mr. Sun, an old lottery player in Shengzhou, followed a group of lottery tickets for a long time, spending 218 yuan a week to follow 109 lottery tickets. Sometimes he doesn’t have time, he will entrust a nearby sports lottery station to buy it. On November 5, Mr. Sun WeChat entrusted Xiao Xu to buy tickets. Xiao Xu is 23 years old. He has just opened this sports lottery station for two months.

　　On the night of the Super Lotto, two of the lottery numbers purchased by Mr. Sun won the first prize, and the bonus for each note was 7114758 yuan. In this way, Mr. Sun won more than 14 million yuan.

　　Mr. Sun was so excited that he called Xiao Xu immediately. Xiao Xu also confirmed that Mr. Sun won the lottery. Who knows that after this call, Xiao Xu can’t contact and the store is closed.

　　Seeing that the prize is about to be redeemed, but the lottery ticket is not available, Mr. Sun is anxious.

　　There is only one lottery ticket.

　　There are two winners.

　　The lottery ticket that won the grand prize is in the hand of Mr. Ying, a friend of Xiao Xu. What’s going on?

　　The following is Xiao Xu’s self-report:

　　On the morning of November 3rd, Mr. Ying came to my shop. He only bought scratch music before, and this time he asked me how to buy the lotto. I recommend him to buy a set of numbers that Mr. Sun often calls. In the evening, we watched TV together. On November 4th, at about two o’clock in the morning, he gave me 220 yuan to buy lottery tickets. But the lottery machine was off at that time, so I told him to help him type out the lottery ticket the next day. Unfortunately, I forgot later.

　　On November 5, I asked Mr. Sun on WeChat as before if he wanted to type out the lottery ticket he had been following. Mr. Sun said yes, so I typed the ticket for him.

　　After the lottery that night, Mr. Sun called me, and I was very excited. But this time I remembered that I only had one set of lottery tickets.

　　I’m a little flustered, because it’s more than 10 million yuan after all, and we ordinary people can’t earn so much money in our lifetime.

　　Who will win the lottery? Mr. Ying told Xiao Xu that he had called and paid the money on the spot, so the lottery ticket belonged to him. So, Xiao Xu handed the lottery ticket to Mr. Ying that night.

　　Who should the lottery go to?

　　Shopkeepers, they asked seven lawyers.

　　Xiao Xu said that he later found that there were more than 20 people around the door of the store, and he panicked, so he turned off his mobile phone and the store was closed.

　　Here, Mr. Sun, who was in a hurry to get angry, consulted a lawyer, and the lawyer suggested applying to the court for property preservation.

　　On November 7, when Mr. Ying took the lottery ticket to win the prize, he found that it had been frozen.

　　For the ownership of the grand prize, the two began to negotiate.

　　Xiao Xu also clarified to us that he has been negotiating with two lottery buyers and has not run away. "When people see me close the door, they must think I’m looking for ‘ Tuo ’ Stealing the grand prize, or I ran away with the lottery ticket. In fact, the next day, I contacted Mr. Sun with my mother’s number and told the story, which was evidenced by the call record. "

　　Xiao Xu said that for this matter, he and Mr. Ying consulted different lawyers seven times. "Shengzhou consulted four and Hangzhou asked three."

　　Xiao Xu is concerned about whether he is responsible for this matter. What Mr. Ying asked is whether he can win the grand prize.

　　Lawyer: Let’s see whose evidence is reliable.

　　Who should win the grand prize? Let’s listen to the lawyer.

　　Lawyer Chen Yilai of Zhejiang Times Commercial Law Firm analyzed: Mr. Sun entrusted Xiao Xu to buy lottery tickets through WeChat, and the entrustment relationship was still established whether he paid or not. If Mr. Sun can’t get the lottery ticket, he can file a lawsuit, and the WeChat message between him and Xiao Xu can be used as electronic evidence.

　　What about Mr. Ying? According to Xiao Xu, Mr. Ying paid in cash at that time, accompanied by Mr. Ying’s wife and a friend, and there was no other physical evidence. The lawyer explained that the key evidence identification mainly lies in documentary evidence, and witness testimony has only an auxiliary role, while the effectiveness of interested witness testimony needs to be verified.

　　If Mr. Ying wants to get back the lottery prize, he can sue Xiao Xu and ask the other party to compensate according to the amount of the winning lottery ticket. This is a typical contract breach lawsuit. But effective and sufficient evidence must be provided.

　　Outcome: Who will get 14 million yuan?

　　On November 9th, the lawyers of Mr. Ying and Mr. Sun negotiated, and the lottery ticket went to Mr. Sun. After that, the lottery ticket was successfully redeemed and the sports lottery station reopened on the same day.

　　Mr. Ying, who passed the grand prize, said that his mood these days is like riding a roller coaster, going back and forth from the peak to the bottom countless times. However, he and Xiao Xu have been friends for many years. If they cut off contact for lottery tickets, it would not be worth the loss, so they have no intention to sue Xiao Xu.

　　Our reporter Wang Zifang Wen/photo