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Xie Zhonghua, secretary of the Political and Legal Committee, was dismissed four months later.

According to official website, the Supervisory Committee of the Sichuan Provincial Commission for Discipline Inspection, on January 12:Xie Zhonghua, former member of the Standing Committee of Panzhihua Municipal Committee and former secretary of the Political and Legal CommitteeSuspected of serious violation of discipline and law, he is currently undergoing disciplinary review and supervision investigation.

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Xie Zhonghua was born in 1964.Long-term work in Sichuan political and legal fieldHe used to be: deputy detachment leader, detachment leader, deputy director, detachment leader of criminal investigation team and executive deputy director of Panzhihua Public Security Bureau.

In September 2011, he served as deputy mayor of Ya ‘an City and director of the Municipal Public Security Bureau. In September 2016, he was transferred to the Standing Committee of Panzhihua Municipal Committee, Secretary of the Political and Legal Committee and Secretary of the Ethnic Affairs Committee.

The official resume shows that last September,Xie Zhonghua’s three positions as member of the Standing Committee of Panzhihua Municipal Committee, secretary of the Political and Legal Committee and secretary of the People’s Religious Affairs Committee were all removed and became "working in Panzhihua Municipal Committee"Four months later, this time.

On the afternoon of April 10 last year,Xie Zhonghua, then member of the Standing Committee of Panzhihua Municipal Committee, secretary of the Political and Legal Committee, and deputy head of the leading group for education and rectification of municipal law team.Hosted a special heart-to-heart talk meeting and held a collective heart-to-heart talk with the "top leaders" of municipal political and legal units.

He stressed that,We must adhere to the policy of "lenient self-examination and strict investigation", take "self-examination and self-correction, organization and investigation, and special rectification" as the starting point, resolutely eliminate the black sheep and thoroughly rectify stubborn diseases., in the political and legal team to form a clear and refreshing relationship between colleagues and comrades, in law enforcement and judicial activities to form a clean relationship between politics and business, police and people, comprehensively improve the purity of the political and legal team, and promote the comprehensive and strict management of the party and police to develop in depth.

On May 10th last year,At that time, Xie Zhonghua, member of the Standing Committee of Panzhihua Municipal Committee, secretary of the Political and Legal Committee, deputy head of the education and rectification leading group of the municipal law team and director of the office, conducted field research and supervised the education and rectification work.

Xie Zhonghua pointed out that political and legal units at all levels should resolutely prevent complacency and relax, continue to deepen their understanding of the importance and urgency of education rectification, effectively carry out study and education throughout, consolidate their ideological foundation, thoroughly examine problems, and thoroughly rectify stubborn diseases.

Xie Zhonghua emphasized that the political position should be further improved.At present, the education and rectification of the political and legal team is in the "deep water area" where it is really hard and touches the key. The more political and legal units should keep a clear head.The more we must adhere to political guidance, set a benchmark by ourselves, and press ourselves, so as to truly promote the prescribed actions in an orderly manner, with distinctive characteristics of optional actions, and effectively improve the pertinence and effectiveness of education rectification.

On November 29th last year, the Information Office of Sichuan Provincial People’s Government held a press conference on the education and rectification of the second batch of political and legal teams in Sichuan Province in Chengdu.

According to the press conference:

筑牢政治忠诚。各政法机关深入贯彻习近平法治思想，深入开展党的十九届六中全会精神“大学习大研讨大培训”活动，深入开展“流毒怎么看、流毒怎么防、流毒怎么清”主题大讨论，组织全体干警签订《全面肃清流毒影响承诺书》，坚决彻底肃清周永康、孙力军等流毒影响，净化政治生态。紧密结合党史学习教育，深入开展政治教育、警示教育、英模教育，开展各类集中学习教育900余场次，教育引导广大干警不断增强“四个意识”、坚定“四个自信”、做到“两个维护”。

清除害群之马。四川深挖彻查案件线索，从严正风肃纪反腐。开展全覆盖、多轮次谈心谈话1万余人次，深入解读“自查从宽、被查从严”政策，组织全体干警开展自查事项填报，截至11月24日，22名干警主动投案。强化组织查处，省纪委监委充分发挥案件查办“主攻手”作用，持续加强纪法协力、监检协同，先后查处了省检察院检委会原专职委员蒋世林、省多元矛盾化解办原专职副主任邢林等一批有影响力的案件。截至11月24日，共立案审查调查省级政法机关干警58人，留置9人，移送司法机关3人，处分处理60人。检察机关立案查办司法工作人员相关职务犯罪72人，同比增长89.5%。

Resume of Xie Zhonghua

Xie Zhonghua, male, Yi nationality, born in September 1964, from Yanbian, Sichuan Province, holds a university degree in the Party School of the Provincial Party Committee. He joined the work in December 1982 and joined the Communist Party of China (CPC) in August 1995.

From December 1982 to December 1995, he worked in Yanbian County Public Security Bureau and served as an investigator and deputy captain of the criminal police team.

From December 1995 to September 2011, he worked in Panzhihua Public Security Bureau, and served as an investigator of the anti-drug brigade, deputy detachment leader of the anti-drug detachment, detachment leader of the anti-drug detachment, member of the bureau party Committee, deputy director, detachment leader of the criminal investigation detachment, deputy secretary of the bureau party Committee and executive deputy director;

From September 2011 to September 2016, he served as deputy mayor of Ya ‘an Municipal Government and director of the Municipal Public Security Bureau;

From September 2016 to September 2021, he served as member of the Standing Committee of Panzhihua Municipal Committee, secretary of the Political and Legal Committee, and secretary of the Ethnic Affairs Committee;

In September 2021, he worked in Panzhihua Municipal Committee.

It was investigated in January 2022.

Yu Gang, former member of the Party Committee and deputy general manager of Guangdong Guangsheng Holding Group Co., Ltd., was "double-opened"

According to the news from the Guangdong Provincial Commission for Discipline Inspection, with the approval of the Guangdong Provincial Party Committee, a few days ago, the Guangdong Provincial Commission for Discipline Inspection conducted a case review and investigation on Yu Gang, former member of the Party Committee and deputy general manager of Guangdong Guangsheng Holding Group Co., Ltd.

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After investigation, Yu Gang lost his ideals and beliefs, abandoned his original mission, was disloyal and dishonest to the party, and confronted organizational censorship; Ignoring the spirit of the eight central regulations, illegally accepting gifts and gifts; Lack of organizational principles, failure to report personal matters in accordance with regulations, and use authority violations to seek benefits for relatives in the recruitment and promotion of cadres; Failing to control and teach one’s family, and conniving at relatives to seek personal gain by using the influence of their positions; Engage in power and money transactions, use the convenience of his position to seek benefits for others in project contracting, share acquisition, product sales, etc., and illegally accept huge amounts of property.

Yu Gang seriously violated the party’s political discipline, organizational discipline, integrity discipline and life discipline, constituted a serious duty violation and was suspected of accepting bribes, and did not stop after the 18th National Congress of the Communist Party of China, which was serious in nature and had a bad influence, and should be dealt with seriously. According to the Regulations on Disciplinary Actions in the Communist Party of China (CPC), the Supervision Law of People’s Republic of China (PRC), the Law on Administrative Actions of Public Officials in People’s Republic of China (PRC) and other relevant regulations, after being studied by the Standing Committee of the Provincial Commission for Discipline Inspection and reported to the provincial party Committee for approval, it was decided to expel Yu Gang from the party; The provincial supervisory Committee gave him the punishment of dismissal from public office; Collect their illegal income; The suspected crime was transferred to the procuratorate for review and prosecution according to law, and the property involved was transferred together.

Resume of Yu Gang

Yu Gang, male, Han nationality, born in November 1966, Linxiang, Hunan, with a bachelor’s degree, joined the work in July 1989 and joined the Communist Party of China (CPC) in December 1986.

In December 1998, he served as deputy director of the production and operation department of Changsha Nonferrous Metallurgical Design and Research Institute.

In January 2000, he served as director of the production and operation department of Changsha Nonferrous Metallurgy Design and Research Institute.

In March 2007, he served as assistant to the president of Changsha Nonferrous Metallurgy Design and Research Institute.

In March 2011, he served as executive director and deputy general manager (presiding) of Changsha Nonferrous Metallurgical Design and Research Institute Co., Ltd.

In March 2013, he served as the general manager of Changsha Nonferrous Metallurgical Design and Research Institute Co., Ltd.

In June 2014, he served as the executive vice president of Shenzhen Zhongjin Lingnan Nonferrous Metals Co., Ltd.

In July 2014, he served as the director and executive vice president of Shenzhen Zhongjin Lingnan Nonferrous Metals Co., Ltd.

In June 2015, he served as deputy secretary, director and president of the Party Committee of Shenzhen Zhongjin Lingnan Nonferrous Metals Co., Ltd.

In September 2017, he served as deputy secretary and chairman of the Party Committee of Shenzhen Zhongjin Lingnan Nonferrous Metals Co., Ltd.

In May 2018, he served as Party Secretary and Chairman of Shenzhen Zhongjin Lingnan Nonferrous Metals Co., Ltd.

In December 2020, he served as member of the Party Committee and deputy general manager of Guangdong Guangsheng Asset Management Co., Ltd.

In March 2021, he served as member of the Party Committee and deputy general manager of Guangdong Guangsheng Holding Group Co., Ltd.

In October 2021, he was removed from the post of Party Committee member and deputy general manager of Guangdong Guangsheng Holding Group Co., Ltd.

Ge Xiuquan, former party member and deputy director of the Standing Committee of Xiangyang Municipal People’s Congress in Hubei Province, was "double-opened"

According to the news from the Supervision Committee of Hubei Provincial Commission for Discipline Inspection: Recently, with the approval of Hubei Provincial Committee, the Supervision Committee of Hubei Provincial Commission for Discipline Inspection made a decision on the former party member and deputy director of Xiangyang Municipal People’s Congress Standing Committee.Ge XiuquanInvestigation on serious violations of discipline and law.

Ge Xiuquan data map

After investigation, Ge Xiuquan violated political discipline, colluded with others, forged evidence, and resisted organizational censorship. Violation of the spirit of the eight central regulations, illegal receipt of gifts and consumption cards; Violation of organizational discipline, failure to truthfully explain problems when organizing letters and inquiries, seeking benefits for others and accepting property in the selection and appointment of cadres. Violation of national laws and regulations, taking advantage of his position to seek benefits for others, and illegally accepting other people’s property, the amount is particularly huge. Engaging in malpractices for selfish ends, abusing power, and illegally approving enterprises to declare special subsidy funds, causing heavy losses to public property, is suspected of abusing power.

As a leading cadre in party member, Ge Xiuquan lost his ideals and beliefs, betrayed his initial mission, was disloyal and dishonest to the Party, abused power for personal gain, accepted bribes, and did not stop after the 18th Party Congress, which seriously violated the Party’s discipline and national laws, and constituted a duty violation and was suspected of a duty crime. According to the Regulations on Disciplinary Actions in the Communist Party of China (CPC), the Supervision Law of People’s Republic of China (PRC) and the Law on Administrative Actions of Public Officials in People’s Republic of China (PRC) and other relevant regulations, Ge Xiuquan was decided to be expelled from the Party after being studied at the meeting of the Standing Committee of the Hubei Provincial Commission for Discipline Inspection and reported to the Hubei Provincial Party Committee for approval. The provincial supervisory Committee gave him the punishment of dismissal from public office; Collect their illegal income; The suspected crime was transferred to the procuratorate for review and prosecution according to law, and the property involved was transferred together.

Ge Xiuquan’s resume

Ge Xiuquan, male, Han nationality, born in September 1964, from Gucheng, Hubei Province, joined the work in August 1986, and joined the Communist Party of China (CPC) in December 1989. He holds a postgraduate degree in the Party School of the Provincial Party Committee.

From December 2000 to January 2002, he served as a member of Gucheng County Committee of Xiangyang City, secretary of the Party Committee of Shihua Town, and secretary of the Party Committee of Shihua Spark Intensive Area;

From January 2002 to December 2003, he served as member of the Standing Committee of Laohekou Municipal Committee of Xiangyang City and deputy mayor;

From December 2003 to October 2008, he served as member of the Standing Committee of Xiangcheng District Committee of Xiangyang City and executive deputy head of the district government;

From October 2008 to April 2010, he served as the executive deputy director of Xiangfan Entrepreneurship Service Bureau;

From April 2010 to December 2010, he served as member and deputy director of the Party Committee of Xiangfan Economic and Information Technology Commission, and secretary and director of the Party Group of the Municipal Entrepreneurship Service Bureau;

From December 2010 to March 2012, he served as member and deputy director of the Party Committee of Xiangyang Economic and Information Technology Commission, and party secretary and director of the Municipal Entrepreneurship Service Bureau;

From March 2012 to January 2017, he served as secretary and director of the Party Committee of Xiangyang Economic and Information Technology Committee and secretary of the National Defense Science and Technology Working Committee of the Municipal Party Committee;

In January 2017, he served as a member of the party group and deputy director of the Standing Committee of Xiangyang Municipal People’s Congress.

Bailuzhou Zhizheng (hxdbxw) integrates the website of the State Commission for Discipline Inspection of the Central Commission for Discipline Inspection, official website, Zheng Shier, Guangdong Commission for Discipline Inspection, Hubei Commission for Discipline Inspection, etc.

Editor Wu Di

　　Introduction to the exhibition

　　This exhibition is a professional exhibition in the field of animation exhibition, and it is a large-scale party carnival with rich and wonderful contents, integrating restoring the world of the second dimension, entertainment interaction and viewing activities. It is a large-scale animation game exhibition with a large number of Coser, visitors and super fun.

　　The main activities include:

　　Interactive experience of animation games, derivative products of animation games, animation game software and peripheral devices; Animation game equipment, hand-painted articles, peripheral products, comic books, children’s picture books, sketchbooks, trendy games, cards, hand-made, models, comic books for teenagers, animation handicrafts, clothing accessories, animation diet, animation cars (painful cars), display and sales of derivatives, cosplay contest, Hanfu contest, and signing meeting of animation guests.

　　Exhibition time: June 8, 2024 to June 9, 2024 from 9: 00 to 17: 00.

　　Venue: Shougang Convention and Exhibition Center

　　Traffic information: The new Shougang subway station can be reached. There are many self-driving parking lots, which can be parked according to the signs around the venue.

　　Suitable for people: industrial enterprises, cartoon game lovers and teenagers.

　　Nanning, China News Service, July 22 nd Title: The Growth of ASEAN Fruits in China: From "Luxury Goods" to "Explosive Prices"

　　Author Zhong Jianshan Huang Cong

　　In the hot midsummer night, in the night market food street in Pingxiang, a border town between China and Vietnam, a small shop named "Hu Xishi Fruit Fishing" is the most lively scene. Diners from all over China queue up to buy a bowl of authentic Southeast Asian fruit fishing.

　　The clerk quickly diced fresh tropical fruits and put them in a transparent glass bowl, covered with corn kernels, red beans and shredded coconut, poured two spoonfuls of thick and fragrant condensed milk, and a bowl of refreshing and sweet fruit fishing can be served.

　　"Fruit fishing is a hot item in Pingxiang. The fruit is fresh and varied, and it tastes delicious and fragrant." Luo Zi, a frequent visitor to Hu Xishi’s fruit fishing shop, said that a bowl of fruit fishing brought together fruits from many countries in Southeast Asia was only sold in 10 yuan RMB, which was "too cost-effective".

　　Pingxiang is the most convenient land route from China to Viet Nam and even ASEAN countries, and has maintained the status of "China’s largest fruit import and export city" for five consecutive years. Every year, more than 1 million tons of fruits are imported and exported from Pingxiang Friendship Pass and Puzhai Port, with more than 500,000 tons of imported fruits. Every 500 grams of ASEAN fruits entering China are imported through Pingxiang.

　　"In the past, the cost of importing fruits from Southeast Asia to China was high, the cold chain logistics network was not perfect, and the border clearance time was long, which led to the high price of fruits in Southeast Asia in China." Chen Renqi, general manager of Guangxi Hongguihua Import and Export Trading Co., Ltd., said in an interview with a reporter from China News Service that his company has been engaged in the import trade of Vietnamese dragon fruit for 22 years, during which he witnessed the change of fruits in Southeast Asia from "luxury goods" to "explosive prices".

　　Chen Renqi said that because the pitaya with white fruit pulp has the advantage of low sugar, the early import of pitaya from Vietnam was mainly aimed at domestic diabetic patients and high-end consumers. With China — With the establishment of ASEAN Free Trade Area, China and ASEAN countries have strengthened cooperation in customs clearance and transportation interconnection, and a large number of fruits from Southeast Asia, such as pitaya, began to enter China. As the import cost is gradually decreasing, the sales price of pitaya in China is increasingly "close to the people", and it has entered the family recipes of ordinary people.

　　"In the past, Vietnamese dragon fruit had to enter China Port, and it took one day to go through various customs clearance procedures such as inspection and quarantine, and it took two or three days to go through, which was very costly. Now the customs clearance time has been reduced to one hour, which is too convenient. " Chen Renqi said that there is a great demand for fruits from Southeast Asia in the China market. Apart from traditional sales channels such as farmers’ markets and supermarkets, emerging industries such as chain juice shops, theme restaurants and fruit experience halls with tropical fruits from ASEAN as their main products have also developed rapidly, enriching the dietary choices of China consumers.

　　In Pingxiang City, new dishes of Chinese food mixed with ASEAN fruits such as stewed pork ribs with peaches, steamed pear, stewed chicken soup with grapes and fried beef with dragon fruit have become the "new favorites" of local people in recent years. Recently, the fruit specialty restaurant and fruit experience center in China Pingxiang, the first fruit city in ASEAN, officially opened its doors for guests. The local official plans to deeply integrate the fruit trade industry with the tourism industry, and make the one-stop shopping and special fruit meals of ASEAN special fruits a new highlight on the tourist route of Friendship Pass.

　　In order to meet the domestic market demand, Chen Renqi’s company has set up several directly affiliated factories and several agent factories in Vietnam. Among them, the factory directly under Panche City, Vietnam is the largest, which can produce 15 containers of pitaya every day. Every year, the company imports pitaya from Vietnam with a total value of 1.5 billion yuan, and fresh fruit is in short supply in China.

　　"We are exploring more kinds of fruit products and sales channels in Southeast Asia." Chen Renqi said that in addition to pitaya, Vietnamese red meat jackfruit has been welcomed by consumers in China in recent years, and the company has also started import business. In Cambodia, the price of local mango fresh fruit has a great advantage over that of China. The company invested 40 million yuan to set up a dried mango processing factory in Cambodia. The dried mango products were transported through Sihanoukville Port, passed through Ho Chi Minh Port in Vietnam to Qinzhou Port in China, and then distributed to all parts of China. At present, the annual output value of dried mangoes exceeds 50 million yuan.

　　Chen Renqi said that more and more China enterprises are joining the fruit industry in ASEAN, which means that the amount of ASEAN fruits entering the China market will continue to expand in the future. In the increasingly perfect environment of international agricultural cooperation and market competition, ASEAN fruit in China "will not increase its quantity, but its quality will be continuously optimized". (End)

At 23: 30 pm Beijing time on October 29th, the 10th round of the 2023-24 Premier League ushered in the first Manchester City Derby of this season, and Manchester United played against Manchester City at Old Trafford Stadium. In the first half, Hoyle pulled Rodley down and sent a penalty, and Harland took the penalty and hit it; In the second half, Harland scored twice with another goal, and before the end, he assisted Foton to seal the victory. Onana made many dives in the audience. In the end, Manchester City beat Manchester United 3-0 away.

This game is the 191st Manchester City Derby in history. Before the game, a series of activities were held at Old Trafford Stadium to commemorate the legendary Sir Bobby Charlton.

In the second minute, Manchester United stole the ball in midfield, and McTominay took the ball to the front of the penalty area and shot it with his left foot. The ball was not strong enough for Edersen. In the 8th minute, Rodley in the frontcourt hoisted the ball into the right side of the penalty area, Walker put it in front of the baseline and knocked the ball across the middle. Foden’s header was saved by Onana.

In the 12th minute, Grali took the ball to the left side of the penalty area, but he passed it back to his opponent in an inverted triangle. Hoyle took the ball and pushed it forward. Unfortunately, his teammates responded too slowly, and the fast break turned into a sports war. In the 15th minute, Foton sent a straight plug from the midfield, and Onana rushed out of the penalty area to clear the ball before Harland did.

In the 20th minute, Manchester City kicked the left tactical corner, Grali grabbed the ball from the right side of the restricted area and shot the far corner, and Onana saved the ball.In the 26th minute, Manchester City won a free kick in the frontcourt, and the ball was hoisted into the penalty area. Rodley, who was fighting for the landing point, was pulled down by Hoyle, and the referee awarded a penalty after watching VAR.

The penalty was taken by Harland, who shot his left foot low in the lower right corner of the goal and tricked Onana into scoring the ball. Manchester City led Manchester United 1-0.

In the 31st minute, Manchester City made a mistake in the frontcourt return, and Hoyle got the ball and got a half-single-handed chance. After he passed the goalkeeper, he didn’t have an angle to shoot, and then he crossed the middle. Unfortunately, B shot high from a small angle.

In the 36th minute, Manchester City made a cross from the right in the frontcourt. Maguire’s header in the penalty area was on Dallot, and he was almost attacked by Grali. In the 37th minute, Manchester City got a free kick from the left outside the penalty area, and Alvarez shot directly, and Onana saved the ball.

In the 45th minute, Manchester United made a long pass from the right side of the midfield. At the top of the arc, McTominay stopped the ball and turned to volley. Edersen saved the ball with one hand. In the 45th+4th minute, Seat B made a forward pass on the left baseline of the restricted area, and Harland headed Taishan in the small restricted area, and Onana flew to dedicate himself. At the end of the first half, Manchester City temporarily took the lead.

In the second half, Yi Bian fought again. In the 48th minute, B Fei received a tactical corner kick in front of the penalty area and made a long shot. Edersen saved the ball. In the 56th minute, Grali took the ball to the far corner from the left side of the restricted area, and Onana saved the ball sideways.In the 50th minute, the B-seat caught the ball and came to the bottom line on the left side of the penalty area. Harland in the middle headed the goal. This time, Onana had no choice. Manchester City led Manchester United 2-0.

In the 58th minute, Alvarez directly blocked the left side of the restricted area at the top of the arc, and Grali made a small-angle volley, and the ball missed the far post. In the 66th minute, Seat B shot with his left foot in front of the penalty area, and Onana hugged the ball. In the 69th minute, Rachford moved forward into the restricted area, and after receiving a long pass from the midfield, he shot low from a far corner at a small angle, and the ball missed slightly.

In the 71st minute, Grali sent a straight plug in the frontcourt, and Harland caught the ball to form a single knife. His volley on the left side of the restricted area was blocked by the attacking Onana. A minute later, Lindelov and Onana’s continuous mistakes almost gave Manchester City a goal.

In the 80th minute, Rodley took the ball and made a long-range shot in front of the restricted area. Onana saved the ball sideways, Harland got the ball on the left side of the restricted area and then passed it horizontally. Foden in the middle of the road easily shoveled the empty net and Manchester City led Manchester United 3-0.

In the 82nd minute, Manchester City made a cross from the left side of the penalty area. Before the penalty spot, Foden turned his back and hit the door, and the ball only missed a little.

In the end, the whole game ended and Manchester City beat Manchester United 3-0.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

Live broadcast November 30th. According to Beiqing report, Li Tie himself recently found Chen Yiyuan, chairman of the Chinese Football Association, profoundly self -review and sincere apology.mean.

For Li Tie’s future, the Chinese Football Association will submit a report to the superior management department. After approval, it will announce the final result through official channels in December.

Li Tie brought the country’s feet this afternoon to the last outdoor training of this closed training at the Taihu Taihu Football Base in Suzhou.Subsequently, the team will take one day on December 1 and be collectively transferred to Shanghai on December 2 to receive "independent observation".Because some Chinese Super League teams have recently come to Shanghai to prepare for the Chinese Super League, some of the national football will directly meet with the club troops, and the national football coaching team will not arrange any collective training in Shanghai.

On November 30th, Beijing time, the World Table Tennis Championships had officially concluded. The final record of the National Table Tennis was to gain 4 gold medals and lost the men’s doubles championship.

Although there were no 5 gold medals, the results of Guoping are still very good, and it has also received praise from the official social media of the People’s Daily. However, Wang Manyu and Fan Zhendong, who played the best winner this time, did not be named. The only one who was named was Sun Yingsha who had lost the women’s singles championship. It turned out that she was the MVP of this year’s national table tennis, although she Did not win the most gold -content award.

《人民日报》亲自开口谈到了国乒这次的情况，并且晒出了九宫格图片，九宫格当中也是有国乒本次出征的大部分主力选手，包括孙颖莎，王曼昱，樊振东，梁靖崑，以及王楚钦和Lin Gaoyuan, Chen Meng and Wang Yidi and others.

They also accompanied: "The Houston World Table Tennis Championships ended in 2021, and the Chinese team ended with four gold results." Then he specifically designed Sun Yingsha: "Sun Yingsha World Table Tennis Championship harvested 2 gold and 1 silver. Each point is every point. Not easy, every player is good, hard, Chinese table tennis, pride for you! "

They recognized Sun Yingsha’s series of contributions, so they mentioned that Sun Yingsha’s two gold and one silver alone, which shows that Sun Yingsha is the real MVP. Wang Manyu did win, and completed the double championship and won the championship of the women’s singles and women’s doubles, but her performance was not as good as Sun Yingsha. Although Sun Yingsha said that the women’s singles won the runner -up, she was in the mixed doubles and her All the women’s double -line operations won the gold medal, and even Sun Yingsha was a third -line operation.

One day before the start of the final, Sun Yingsha even played 4 games in one day, a mixed doubles semi -final and a mixed doubles final, and there were two semi -finals of women’s singles and women’s doubles. Playing 4 games a day and remained full of victory. More importantly, Sun Yingsha defeated the Japanese team’s five giants Zhang Benzhi, Ito Makoto, Hayawa Miyu, Ishikawa Jiachun.

She defeated Hirano Miyu and Ishikawa Jiachun in the 1/4 finals of the Women’s Doubles, and defeated Ito Makoto and Haya Hina in the women’s doubles finals. Facing the Japanese five giants, people played 9 wins and 2 losses. The third -tier operations were better than Wang Manyu. She was the real MVP. Sun Yingsha.

What’s more?

Wang Manyu has only two gold medals, and the mixed doubles competition will go out early, but Sun Yingsha is 2 gold and 1 silver, so the "People’s Daily" will specifically recognize her. She is the real MVP. Only she has received such treatment. Liu Guoliang recognizes her. Normally, this is the treatment of the next Grand Slam and the National Table Tennis Demon King.

This may also be why Liu Guoliang and Li Yan will personally serve as Sun Yingsha’s coaches during this World Table Tennis Championships, find a problem for her, and give her a guest to feed her the ball. On the one hand, it is indeed because Sun Yingsha has no supervisor in charge, and on the other hand, it may be because Sun Yingsha has always been Liu Guoliang’s favorite first love general.